PUBLICATIONS

JOURNAL ARTICLES

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  1. Rammos A, Gonzalez LAN; Schizophrenia Working Group of the Psychiatric Genomics Consortium 2,, Weinberger DR, Mitchell KJ, Nicodemus KK. The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia. Neuropsychopharmacology. 2019 May 11. doi: 10.1038/s41386-019-0410-z.

  2. Okada T, Keino-Masu K, Suto F, Mitchell KJ, Masu M. Remarkable complexity and variability of corticospinal tract defects in adult Semaphorin 6A knockout mice. Brain Res. 2019 May 1;1710:209-219. doi: 10.1016/j.brainres.2018.12.041.

  3. Mitchell KJ. Does Neuroscience Leave Room for Free Will? Trends Neurosci. 2018 Jun 7. pii: S0166-2236(18)30155-3.

  4. Mitchell KJ. Revealing the Genetic Instructions for Nervous System Wiring. Trends Neurosci. 2018 Jul;41(7):407-409.

  5. Mitchell KJ. Neurogenomics - towards a more rigorous science. Eur J Neurosci. 2018 Jan;47(2):109-114. doi: 10.1111/ejn.13801.

  6. Mitchell KJ. (2018) What are the Laws of Biology? The Biologist 64(6) p6.

  7. Bibollet-Bahena, O., Okafuji, T., Hokamp, K., and Mitchell, K.J. (2017) A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One 2017 May 30;12(5):e0177977.

  8. Mitsogiannis MD, Little GE, Mitchell, KJ. (2017) Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance. Neural Development 12(1):6.

  9. Håkansson K, Runker AE, O'Sullivan GJ, Mitchell KJ, Waddington JL, O'Tuathaigh CM. (2017) Semaphorin 6A knockout mice display abnormalities across ethologically-based topographies of exploration and in motor learning. Neurosci Lett. Feb 22;641:70-76.

  10. Farina FR, Mitchell KJ*, Roche RA*. Synaesthesia lost and found: two cases of person- and music-colour synaesthesia. Eur J Neurosci. 2017 Feb;45(3):472-477. *joint senior author

  11. O'Tuathaigh CM, Fumagalli F, Desbonnet L, Perez-Branguli F, Moloney G, Loftus S, O'Leary C, Petit E, Cox R, Tighe O, Clarke G, Lai D, Harvey RP, Cryan JF, Mitchell KJ, Dinan TG, Riva MA, Waddington JL. (2016) Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1. Schizophr Bulletin Sep 9. pii: sbw120

  12. Perez-Branguli F, Zagar Y, Shanley DK, Graef IA, Chédotal A, Mitchell KJ. Reverse Signaling by Semaphorin-6A Regulates Cellular Aggregation and Neuronal Morphology. PLoS One. 2016 Jul 8;11(7):e0158686.

  13. Cate, S., Gajendra, S., Alsbury, S., Raabe, T., Tear, G. and Mitchell, K.J. (2016). Mushroom body defect is required in parallel to Netrins for midline axon guidance in Drosophila. Development 143:972-7

  14. Pini G, Congiu L, Benincasa A, DiMarco P, Bigoni S, Dyer AH, Mortimer N, Della-Chiesa A, O'Leary S, McNamara R, Mitchell KJ, Gill M, Tropea D. Illness Severity, Social and Cognitive Ability, and EEG Analysis of Ten Patients with Rett Syndrome Treated with Mecasermin (Recombinant Human IGF-1). Autism Res Treat. 2016;2016:5073078.

  15. Tropea, D., Molinos, I., Petit, E., Bellini, S., Nagakura, I., O’Tuathaigh, C., Schorova, L., Mitchell, K.J., Waddington, J., Sur, M., Gill, M., and Corvin, A.P. (2016). Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro. Translational Psychiatry 6:e712. doi: 10.1038/tp.2015.206.

  16. Newell, F.N. and Mitchell, K.J.* (2015). Multisensory integration and cross-modal learning in synaesthesia: a unifying model. Neuropsychologia 2015 Jul 29. pii: S0028-3932(15)30111-1. doi: 10.1016/j.neuropsychologia.2015.07.026

  17. McLysaght A, Makino T, Grayton HM, Tropeano M, Mitchell KJ, Vassos E, Collier DA.(2014) Ohnologs are overrepresented in pathogenic copy number mutations. Proc Natl Acad Sci U S A. 111(1):361-6.

  18. Dolan, J. and Mitchell, K.J. (2013) Mutation of Elfn1 in mice causes seizures and hyperactivity. PLoS One Nov 27;8(11):e80491.

  19. O’Hanlon, E., Newell, F. and Mitchell, K.J. (2013) Combined structural and functional imaging reveals cortical deactivations in grapheme-colour synaesthesia. Frontiers in Psychology 4:755. doi: 10.3389/fpsyg.2013.00755

  20. Mitchell, K.J. (2013). Genetic entropy and the human intellect. Trends in Genetics

  21. Mitchell, K.J. (2012). What is complex about complex disorders? Genome Biol. 13, 237

  22. Mitchell, K.J., Huang, Z.J., Moghaddam, B. and Sawa, A. (2011). Following the genes: a framework for animal modelling of psychiatric disorders. BMC Biology 9, 76. Part of the Wiring the Brain Thematic Series:

  23. Mitchell, K.J. (2011). The Genetic Architecture of Behavioural Traits.  Discussion on ‘Heritability in the Era of Molecular Genetics: Some Thoughts for Understanding Genetic Influences on Behavioural Traits’, by W. Johnson et al.  European Journal of Personality. European Journal of Personality, Eur. J. Pers. 25: 267–286

  24. Rünker A.E., O'Tuathaigh, C., Dunleavy, M., Morris, D.W., Little, G.E., Corvin, A.P., Gill, M., Henshall, D.C., Waddington, J.L. and Mitchell, K.J. (2011).  Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology. PLoS One 6(11):e26488

  25. Mitchell, K.J. (2011) The miswired brain: making connections from neurodevelopment to psychopathology. BMC Biol. 12;9:23.  Part of the Wiring the Brain Thematic Series.

  26. Mitchell, K.J. (2011) Curiouser and curiouser; genetic disorders of cortical specialisation.  Curr Opin Genetics and Development 21(3):271-7.

  27. Miller-Delaney, S.F.C., Lieberam, I., Murphy, P. and Mitchell, K.J. (2011) Plxdc2 is a mitogen for neural progenitors.  PLoS One 6(1):e14565.

  28. Janssen BJ, Robinson RA, Pérez-Brangulí F, Bell CH, Mitchell KJ, Siebold C, Jones EY. (2010) Structural basis of semaphorin-plexin signalling. Nature 467:1118-22.

  29. Mitchell KJ. (2010) The genetics of neurodevelopmental disease. Curr Opin Neurobiol. 21(1):197-203

  30. Tawarayama H, Yoshida Y, Suto F, Mitchell KJ, Fujisawa H. (2010) Roles of Semaphorin-6B and Plexin-A2 in Lamina-Restricted Projection of Hippocampal Mossy Fibers. Journal of Neuroscience 30:7049-7060.

  31. Mitchell K. (2010). Journal club. A neurodevelopmental geneticist explores how one mutation can lead to multiple diseases. Nature 464 (7292):1107.

  32. Mitchell K.J. and Porteous, D.J. (2011). Rethinking the genetic architecture of schizophrenia. Psychological Medicine 2011 Jan;41(1):19-32. Epub 2010 Apr 12

  33. Mitchell KJ, Porteous DJ. (2009) GWAS for psychiatric disease: is the framework built on a solid foundation? Mol Psychiatry. Aug;14(8):740-1.

  34. Little GE, Lopez-Bendito G, Runker AE, Garcia N, Pinon MC, Chedotal A, Molnar Z, Mitchell KJ. (2009) Specificity and plasticity of thalamocortical connections in Sema6A mutant mice. PLoS Biol. Apr 28;7(4):e98.

  35. Annette E. Runker, Graham E. Little, Fumikazu Suto, Hajime Fujisawa and Kevin J. Mitchell. (2008) Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points. Neural Development 8;3:34.

  36. Bargary G, Barnett, K.J., Mitchell, K.J.* and Newell, F.N.* (2009) Coloured-speech synaesthesia is triggered by multisensory, not unisensory, perception.  Psychological Science 20(5):529-33. (*joint senior authors).

  37. Kylie J. Barnett, John J. Foxe, Sophie Molholm, Simon P. Kelly, Shani Shalgi, Kevin J. Mitchell*, Fiona N. Newell* (2008) Differences in early sensory-perceptual processing in synesthesia: A visual evoked potential study. NeuroImage 43 (2008) 605–613. (*joint senior authors).

  38. Bargary G, Mitchell KJ (2008). Response to Cohen Kadosh and Walsh: Synaesthesia: evaluating competing theories. Trends Neurosci. Sep 17. [Epub ahead of print]

  39. Bargary G, Mitchell KJ. (2008) Synaesthesia and cortical connectivity. Trends Neurosci. Jul;31(7):335-42.

  40. Renaud J, Kerjan G, Sumita I, Zagar Y, Georget V, Kim D, Fouquet C, Suda K, Sanbo M, Suto F, Ackerman SL, Mitchell KJ, Fujisawa H, Chédotal A. (2008) Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells. Nature Neurosci. Apr;11(4):440-9.

  41. Bron R, Vermeren M, Kokot N, Andrews W, Little GE, Mitchell KJ, Cohen J. (2007) Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism. Neural Develop. Oct 30;2:21.

  42. Barnett KJ, Finucane C, Asher JE, Bargary G, Corvin AP, Newell FN, Mitchell KJ. (2008) Familial patterns and the origins of individual differences in synaesthesia. Cognition. 106(2): 871-93. Epub 2007 Jun 27.

  43. Dolan J, Walshe K, Alsbury S, Hokamp K, O'Keeffe S, Okafuji T, Miller SF, Tear G, Mitchell KJ. (2007) The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics. 14;8:320.

  44. Mitchell, K.J. (2007) The genetics of brain wiring; from molecule to mind. PLoS Biology Apr 17;5(4):e113.

  45. Suto, F., Tsuboi, M., Kamiya, H., Mizuno, H., Kiyama, Y., Komai, S., Shimizu, M., Sanbo, M., Yagi, T., Hiromi, Y., Chédotal, A., Mitchell, K.J., Manabe, T., and Fujisawa, H. (2007) Interactions between Plexin-A2, Plexin-A4 and Semaphorin 6A Control Lamina-restricted Projection of Hippocampal Mossy Fibers. Neuron, 53(4):535-47.

  46. Miller, S.F.C., Summerhurst, K., Rünker, A.E., Kerjan, G., Friedel, R.H., Chédotal, A., Murphy, P. and  Mitchell, K.J. (2006) Expression of Plxdc2/TEM7R in the developing nervous system of the mouse. Gene Expression Patterns Apr;7(5):635-44.

  47. Kerjan, G., Dolan, J., Haumaitre, C., Schneider-Maunoury, S., Fujisawa, H., Mitchell, K.J., Chedotal A. (2005) The transmembrane semaphorin Sema6A controls cerebellar granule cell migration.  Nature Neuroscience 8, 1516-24.

  48. Leighton, P.A.*, Mitchell, K.J.*, Goodrich, L.V.*, Lu, X., Pinson, K.I., Scherz, P., Skarnes, W.C., and Tessier-Lavigne, M. (2001). Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature 410, 174-179. (*joint first authors).

  49. Mitchell, K.J.*, Pinson, K.I.*, Kelly, O.G., Brennan, J., Zupicich, J., Scherz, P., Leighton, P.A., Goodrich, L.V., Lu, X., Avery, B.J., Tate, P., Dill, K., Pangilinan, E., Wakenight, P., Tessier-Lavigne, M., and Skarnes, W.C. (2001). Functional analysis of secreted and transmembrane proteins critical to mouse development. Nature Genetics 28, 241-249. (*joint first authors).

  50. Winberg, M.L., Mitchell, K.J., and Goodman, C.S. (1998). Complementary and combinatorial functions of Netrins, Semaphorins, and Ig-CAM's in discrete target selection. Cell 93, 581-91.

  51. Kidd, T., Brose, K., Mitchell, K.J., Fetter, R.D., Tessier-Lavigne, M., Goodman, C.S., and Tear, G. (1997). Roundabout controls axon crossing of the CNS midline and defines a new subfamily of evolutionarily conserved guidance receptors. Cell 92, 205-215.

  52. Kolodziej, P.A., Timpe, L.C., Mitchell, K.J., Fried, S.A., Goodman, C.S., Jan, L.Y., and Jan, Y.N. (1996). frazzled encodes a Drosophila member of the deleted in colon cancer (DCC) immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87, 197-204.

  53. Mitchell, K.J., Doyle, J.L., Serafini, T., Kennedy, T.E., Tessier-Lavigne, M., Goodman, C.S., and Dickson, B.J. (1996). Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons. Neuron 17, 203-215. 

  54. Sharp, PM, Mitchell, KJ (1993). Corynebacterium-glutamicum arginyl-transfer RNA-synthetase.  Molecular Microbiology   Volume: 8   Issue: 1   Pages: 200-200

BOOK CHAPTERS

 

  1. Mitchell, K.J. (2015). The genetic architecture of neurodevelopmental disorders. In: The Genetics of Neurodevelopmental Disorders. Edited by Kevin J. Mitchell. Wiley. http://biorxiv.org/content/early/2014/09/19/009449

  2. Moore, J.H. and Mitchell, K.J. (2015). The role of genetic interactions in neurodevelopmental disorders. In: The Genetics of Neurodevelopmental Disorders. Edited by Kevin J. Mitchell. (2015). Wiley.

  3. Betancur, C. and Mitchell, K.J. (2015). Synaptic disorders. In: The Genetics of Neurodevelopmental Disorders. Edited by Kevin J. Mitchell. (2015). Wiley.

  4. Mitchell, K.J. (2014) The miswired brain - the genetic roots of mental illness “The Future of The Brain: Essays by the World’s Leading Neuroscientists.” Edited by Gary Marcus. Princeton University Press.

  5. Mitchell, K.J., O’Donnell, P., Durstewitz, D., Fenton, A.A., Gingrich, J.A., Gordon, J.A., Kelsch, W., Moghaddam, B., Phillips, W.A. and Sawa, A. (2013) A framework for advancing the use of models in schizophrenia. In Schizophrenia, MIT Press.

  6. Mitchell, K.J. (2013). Synaesthesia and cortical connectivity – a neurodevelopmental perspective. In the Oxford Handbook of Synaesthesia (Eds: J. Simner and E. Hubbard).

  7. Waddington JL, Corvin AP, Donohoe G, O'Tuathaigh CM, Mitchell KJ, Gill M. (2007) Functional genomics and schizophrenia: endophenotypes and mutant models. Psychiatr Clin North Am. 2007 Sep;30(3):365-99.

  8. Mitchell, K.J., et al. (2001). Studying brain development and wiring using a modified gene trap approach. In Methods in Genomic Neuroscience, eds. H.R. Chen and S.O. Moldin  (Boca Raton, FL: CRC Press).

  9. Sharp, P.M., Burgess, C.J., Cowe, E., Lloyd, A.T., and Mitchell, K.J. (1992). Selective use of termination codons and variations in codon choice. In Transfer RNA in Protein Synthesis, eds. D.L. Hatfield, B.J. Lee, and R.M. Pirtle (Boca Raton, FL: CRC Press), pp. 395-420.

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